![]() Journal of the American College of Cardiology, 48, 1018–1026. Coronary artery calcification and myocardial perfusion in asymptomatic adults: The MESA (Multi-Ethnic Study of Atherosclerosis). R., Jr., Shahar, E., Detrano, R., & Folsom, A. AJR: American Journal of Roentgenology, 215, 1–7. ![]() Incidental coronary artery calcification and stroke risk in patients with atrial fibrillation. Association of AHSG gene polymorphisms with serum Fetuin-A levels in individuals with cardiovascular calcification in west of Iran. Mohammadi-Noori, E., Salehi, N., Mozafari, H., EliehAliKomi, D., Saidi, M., Bahrehmand, F., Vaisi-Raygani, A., Elahirad, S., Moini, A., & Kiani, A. Journal of Geriatric Cardiology: JGC, 12, 668–675. Current understanding of coronary artery calcification. ![]() Carriers of A allele in rs243866 SNP and T allele in rs3918242 SNP were shown to have higher MMP-2 and MMP-9 serum levels and activity that may result in increased ECM degradation and support the initiation and development of calcification. Serum levels and activity of MMP-2 and MMP-9 were found to be higher in CAC cases when compared to the healthy controls. Our results showed that both serum levels of MMP-2 and MMP-9 ( P A (rs243866) and MMP-9 -1562 C>T (rs3918242) SNPs, respectively, may predispose the individuals to CAC by acting as the risk factors. Additionally, serum biochemical parameters including FBS (fasting blood sugar), urea, creatinine, cholesterol, triglyceride, HDL (high-density lipoprotein), LDL (low-density lipoprotein), calcium, and phosphorus as well as blood pressure (systolic blood pressure (SBP) and diastolic blood pressure (DBP)) were measured. We also investigated the serum levels of MMP-2 and MMP-9 and their activity using ELISA and gelatin zymography, respectively. One hundred and fifty-five cases with CAC and 155 healthy individuals as control group from West of Iran were included and frequency of genotypes and alleles of rs243866 and rs3918242 in MMP-2 and MMP-9 genes were determined using PCR–RFLP. We sought to investigate the association between MMP-2 -1575G>A (rs243866) and MMP-9 -1562 C>T (rs3918242) SNPs with MMP-2 and MMP-9 serum levels and activity in individuals with CAC. To make a comment you must login or register.The serum levels and activity of matrix metalloproteinases (MMPs) are associated with the risk of coronary artery calcification (CAC). How the AICD may regulate signal transduction is uncertain but the authors found a 3-hour lag between inhibition of γ-secretase and inhibition of Ca2+-signaling, which would be sufficient time to modulate transcription.-Tom Fagan Comments Furthermore, in AβPP-negative cells, Ca2+-signaling was markedly disrupted but could be rescued by transfection with whole AβPP or with just the AICD transfection with an AβPP construct devoid of the AICD failed to restore signaling.Ī role for AICD in regulation of endoplasmic reticulum (ER) calcium was suggested by the fact that PS1/PS2- or AβPP-negative fibroblasts, or those treated with γ-secretase inhibitors had lower ER calcium, an observation that agrees with previous data ( Yoo et al 2000). Calcium signaling was also blocked by γ-secretase inhibitors, which blocked signal transduction as potently as they inhibited the protease. ![]() The authors showed that mouse embryonic fibroblasts devoid of presenilin 1, the likely active component of γ-secretase, poorly mobilized intracellular calcium in response to external stimuli. The researchers report in tomorrow's Proceedings of the National Academy of Sciences that AICD plays an important role in intracellular calcium signaling. Steps toward addressing the latter shortcoming have been taken by an international collaboration lead by Frank LaFerla, University of California at Irvine, and including Michael Wolfe at Harvard Medical School and Bart DeStrooper at Flanders Interuniversity, Leuven, Belgium. However, there is currently no evidence that AICD enters the nucleus, nor have any potential downstream targets of the intracellular domain been identified. This idea is supported by yeast two-hybrid experiments, which show that the AICD can promote transcription of a reporter gene when bound to Fe65, a protein that interacts strongly with histone acetyltransferases (see related ARF news item). The similarities between the γ-secretase-mediated processing of AβPP and the Notch receptor suggest that the AβPP intracellular domain (AICD), like its Notch counterpart, could play a role in signal transduction. ![]()
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